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#Silica gel structure free#
M.S.GEL particles have a near-perfect spherical shape that is free from cavities and cracks. The more spherical the shape, the more homogenous the packing characteristics and the less solvent required for the process. Particle shape can really impact separation efficiency. When selecting silica gel, keep in mind the three physical properties that influence separation: particle shape, particle size and pore diameter. Adsorption and removal of ionized compounds from organic solvents.Separation media for proteins, peptides, and active pharmaceutical ingredients.For example, M.S.GEL™ particles can be bonded with C4, C8, C18, NH2, SP, CM, epoxy, diol and phenyl. Chemical bonding is used to add a stationary phase functional group to the silica gel particle. Silanol groups usually exhibit weak acidity and serve as absorption-active sites. Three types of silanol groups are on the surface of silica gel: isolated, vicinal and germinal. Silica gel is an amorphous silicic acid polymer represented as SiO2-nH2O. When used as a packing medium, this microspherical gel enables a separation process that is highly reproducible. Column packing, separation and purification influence accuracy, making the quality of the silica gel used an incredibly important factor when processing difficult separations.ĪGC Chemicals Americas provides high-purity, porous silica gel with low moisture content and high lot-to-lot consistency. It is a polar absorbent with slight acidity, enabling it to absorb basic contents in a material that needs separation during chromatography, while also remaining neutral and maintaining its own structure throughout the process.įor high-performance liquid chromatography (HPLC), in particular, accuracy is king. Silica gel is one of the most versatile and effective agents used in chromatography today, making it also one of the most popular.